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Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer

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journal contribution
posted on 21.09.2015, 00:00 authored by Sakina M. Petiwala, Angela G. Puthenveetil, Jeremy J. Johnson
The Mediterranean diet is rich in fruits and vegetables and has been associated with a variety of health benefits including cancer prevention. One aspect of the diet that has not received enough attention is Mediterranean herbs. Specifically, rosemary and its polyphenolic diterpenes (carnosic acid and carnosol) are known to possess anti-oxidant activity that may be beneficial for cancer control. Herein, we describe the in vitro and in vivo studies carried out towards understanding the molecular mechanisms of carnosic acid and carnosol leading to inhibition of prostate cancer. The reported findings suggest that these polyphenols target multiple signaling pathways involved in cell cycle modulation and apoptosis. Further work is required to understand its potential for health promotion and potential drug discovery for prostate cancer chemoprevention.

Funding

Aspects of this work was supported by the American Cancer Society RSG CNE-122480 (to Jeremy J. Johnson).

History

Publisher Statement

This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission

Publisher

Frontiers Research Foundation

Language

en_US

issn

1663-9812

Issue date

01/03/2013

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