Precision Medicine Weight Loss paper.Abeer.CLEAN POST RS.12.21.2018.docx (147.4 kB)
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Precision Medicine in Weight Loss and Healthy Living

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journal contribution
posted on 22.05.2019, 00:00 by Richard Severin, Ahmad Sabbahi, Abeer M. Mahmoud, Ross Arena, Shane A. Phillips
Obesity affects 600 million people globally and over one third of the American population. Along with associated comorbidities, including cardiovascular disease, stroke, diabetes, and cancer; the direct and indirect costs of managing obesity are 21% of the total medical costs. These factors shed light on why developing effective and pragmatic strategies to reduce body weight in obese individuals is a major public health concern. An estimated 60-70% of obese Americans attempt to lose weight each year, with only a small minority able to achieve and maintain long term weight loss. To address this issue a precision medicine approach for weight loss has been considered, which places an emphasis on sustainability and real-world application to individualized therapy. In this article we review weight loss interventions in the context of precision medicine and discuss the role of genetic and epigenetic factors, pharmacological interventions, lifestyle interventions, and bariatric surgery on weight loss.


This review was supported in part by NIH training grant T32-HL-139439 (AS) and NIH 1K99HL140049-01 (AMM).


Publisher Statement

NOTICE: This is the author’s version of a work that was accepted for publication in Progress in Cardiovascular Diseases. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Progress in Cardiovascular Diseases, [62, 1, (2019)] DOI:10.1016/j.pcad.2018.12.012


Severin, R., Sabbahi, A., Mahmoud, A. M., Arena, R., & Phillips, S. A. (2019). Precision Medicine in Weight Loss and Healthy Living. Progress in Cardiovascular Diseases, 62(1), 15-20. doi:10.1016/j.pcad.2018.12.012


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