Precision in Promoting Physical Activity and Exercise with the Overarching Goal of Moving More

Physical inactivity is strongly associated with an unfavorable health profile, increasing an individual’s risk for developing cardiovascular disease. Initiating a regular exercise routine contributes to improvements in cardiorespiratory fitness , body composition, resting blood pressure, blood glucose, and circulating lipoproteins. However, the extent to which positive changes occur come with significant inter-individual variability within intervention groups; non-responders and responders have been commonly identified across populations, highlighting that not all exercise regimens are universally effective in all individuals and should therefore not be treated as a “one-size fits all” prescription. Recent studies have therefore emphasized reporting the quantity of participants favorably and meaningfully “responding” to varying amounts and intensities of exercise, thereby presenting the opportunity to view exercise prescription in the context of precision medicine. This review will address the impact of varying amounts and intensities of physical activity and exercise, highlighting their impact on key health metrics.