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Pregnancy outcomes among women receiving RVSVΔ-Zebov-GP Ebola vaccine during the Sierra Leone trial to introduce a vaccine against Ebola
journal contributionposted on 10.06.2021, 17:40 by JK Legardy-Williams, RJ Carter, ST Goldstein, Olamide JarrettOlamide Jarrett, E Szefer, AE Fombah, SC Tinker, M Samai, BE Mahon
Little information exists regarding Ebola vaccine rVSVΔGZEBOV-GP and pregnancy. The Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) randomized participants without blinding to immediate or deferred (18-24 weeks postenrollment) vaccination. Pregnancy was an exclusion criterion, but 84 women were inadvertently vaccinated in early pregnancy or became pregnant <60 days after vaccination or enrollment. Among immediate vaccinated women, 45% (14/31) reported pregnancy loss, compared with 33% (11/33) of unvaccinated women with contemporaneous pregnancies (relative risk 1.35, 95% CI 0.73-2.52). Pregnancy loss was similar among women with higher risk for vaccine viremia (conception before or <14 days after vaccination) (44% [4/9]) and women with lower risk (conception >15 days after vaccination) (45% [10/22]). No congenital anomalies were detected among 44 live-born infants examined. These data highlight the need for Ebola vaccination decisions to balance the possible risk for an adverse pregnancy outcome with the risk for Ebola exposure.
CitationLegardy-Williams, J. K., Carter, R. J., Goldstein, S. T., Jarrett, O. D., Szefer, E., Fombah, A. E., Tinker, S. C., Samai, M.Mahon, B. E. (2020). Pregnancy outcomes among women receiving RVSVΔ-Zebov-GP Ebola vaccine during the Sierra Leone trial to introduce a vaccine against Ebola. Emerging Infectious Diseases, 26(3), 541-548. https://doi.org/10.3201/eid2603.191018
PublisherCenters for Disease Control and Prevention (CDC)
EbolaEbola vaccineEbola virusEbola virus diseaseSTRIVESierra LeoneSierra Leone Trial to Introduce a Vaccine against EbolaWest AfricapregnancyrVSVΔ-ZEBOV-GPvaccine safetyvaccine-preventable diseasesvirusesAdultDouble-Blind MethodEbola VaccinesFemaleHemorrhagic Fever, EbolaHumansPregnancyPregnancy Complications, InfectiousPregnancy OutcomePrenatal CareVaccinationYoung AdultMicrobiologyClinical SciencesMedical MicrobiologyPublic Health and Health Services