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Preliminary Evidence for a Sex-Specific Relationship between Amount of Cannabis Use and Neurocognitive Performance in Young Adult Cannabis Users

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posted on 20.11.2014, 00:00 authored by Natania A. Crane, Randi Melissa Schuster, Raul Gonzalez
Accumulating evidence suggests neuropsychological deficits from cannabis use, with a burgeoning area of preclinical research indicating possible sex-differences. However, few studies have examined how cannabis use may differentially impact neurocognition in male and female cannabis users. As such, we examined potential sex-differences in associations between amount of cannabis use (across several time frames) and neurocognitive performance among young adult regular cannabis users. Consistent with previous studies, more cannabis use was generally associated with poorer episodic memory and decision-making, but not other measures of inhibitory control. However, patterns of results suggested sex-specific dissociations. In particular, more cannabis use was more consistently associated with poorer episodic memory performance in females than males. Conversely, more cannabis use was associated with poorer decision-making performance for males, but not females. These results provide further evidence for residual cannabis-associated neurocognitive deficits and suggest the importance of examining the impact of cannabis on neurocognition separately for males and females


This publication was made possible by the National Institute on Drug Abuse (NIDA) (K23 DA023560, R01 DA031176, and R01 DA033156, PI: RG) and (F31 DA032244-02, PI: RMS); and the National Cancer Institute (NCI) (P01CA098262, PI: RM).


Publisher Statement

This is a copy of an article published in the Journal of the International Neuropsychological Society © 2013 Cambridge University Press. The final version of record is available at doi: 10.1017/S135561771300088X.


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