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Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother / infant pairs

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Version 2 2024-06-03, 16:30
Version 1 2023-12-18, 19:10
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posted on 2024-06-03, 16:30 authored by Alison P. Sanders, Marie Lynn MirandaMarie Lynn Miranda, Rebecca C. Fry, Saideep Gona
A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters (n = 16,421) in leukocytes collected from mothers and their infants from a pregnancy cohort in Durham County, North Carolina. The CpG methylation levels were examined in relationship to prenatal exposure to cadmium and/or cotinine to identify genes and pathways influenced by in utero exposure. In the present article, we provide an enhanced description of the data collection and processing to facilitate cross-study comparisons. Data are available within the Gene Expression Omnibus database (GSE67976).

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