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Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology

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journal contribution
posted on 29.04.2011, 00:00 by Kimberly R. Porter, Bridget J. McCarthy, Sally Freels, Yoonsang Kim, Faith G. Davis
Prevalence is the best indicator of cancer survivorshipin the population, but few studies have focused onbrain tumor prevalence because of previous data limitations.Hence, the full impact of primary brain tumors on the healthcare system in the United States is not completely described. The present study provides an estimate of the prevalence of disease in the United States, updating an earlier prevalence study. Incidence data for 2004 and survival data for 1985–2005 were obtained by the Central Brain Tumor Registry of the United States from selected regions, modeled under 2 different survival assumptions, to estimate prevalence rates for the year 2004 and projected estimates for 2010. The overall incidence rate for primary brain tumors was 18.1 per 100 000 person-years with 2-, 5-, 10-, and 20-year observed survival rates of 62%, 54%, 45%, and 30%, respectively. On the basis of the sum of nonmalignant and averaged malignant estimates, the overall prevalence rate of individuals with a brain tumor was estimated to be 209.0 per 100 000 in 2004 and 221.8 per 100 000 in 2010. The female prevalence rate (264.8 per 100 000) was higher than that in males (158.7 per 100 000). The averaged prevalence rate for malignant tumors (42.5 per 100 000) was lower than the prevalence for nonmalignant tumors (166.5 per 100 000). This study provides estimates of the 2004 (n 5 612 770) and 2010 (n 5 688 096) expected number of individuals living with primary brain tumor diagnoses in the United States, providing more current and robust estimates for aiding healthcare planning and patient advocacy for an aging US population.

Funding

This work was conducted under contract to the Central Brain Tumor Registry of the United States. Funding for this project was provided by the National Brain Tumor Society. K.R.P. was supported by a NCI pre-doctoral fellowship through the cancer prevention and control training grant (5 R25 CA 057699-15, PI Warnecke, RB).

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Publisher Statement

Post print version of article may differ from published version. The definitive version is available through Duke University Press at DOI: 10.1093/neuonc/nop066

Publisher

Duke University Press

Language

en_US

issn

1523-5866

Issue date

01/06/2010

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