Yu C et al Proposed mechanism for lipoprotein remodelling in the brain_BBA2010.pdf (566.2 kB)
Proposed mechanism for lipoprotein remodelling in the brain
journal contribution
posted on 2011-01-10, 00:00 authored by Chunjiang Yu, Katherine L. Youmans, Mary J. LaDuLipoprotein remodelling in the periphery has been extensively studied. For example, the
processing of nascent apoAI particles to cholesterol-loaded HDL lipoproteins during
reverse cholesterol transport involves a series of enzymes, transporters in peripheral
tissue, as well as other apolipoproteins and lipoproteins. These extensive modifications
and interconversions are well defined. Here, we present the hypothesis that a similar
process occurs within the blood brain barrier (BBB) via glia-secreted lipid-poor apoE particles undergoing remodelling to become mature central nervous system (CNS)
lipoproteins. We further pose several pressing issues and future directions for the study of lipoproteins in the brain.
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Publisher Statement
Postprint version of article may differ from published version. The definitive version is available through Elsevier at DOI: 10.1016/j.bbalip.2010.05.001Publisher
ElsevierLanguage
- en_US
issn
1388-1981Issue date
2010-08-01Usage metrics
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