Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis
journal contributionposted on 2019-05-22, 00:00 authored by Ryan W. Dobbs, Neha R. Malhotra, Michael R. Abern, Daniel M. Moreira
BACKGROUND: We sought to evaluate prostate cancer (PCa) characteristics and outcomes of Hispanics living in the United States by country of origin in the Surveillance, Epidemiology and End Results (SEER) program. METHODS: Retrospective analysis of 72,134 adult Hispanics with PCa between 1995-2014. Origin was Mexican (N=16,995; 24%), South/Central American (N=6,949; 10%), Puerto Rican (N=3,582; 5%), Cuban (N=2,587; 4%), Dominican (N=725; 1%), Hispanic not specified (NOS, N=41,296; 57%), as coded by SEER. Patient and PCa characteristics were analyzed with chi-square and Kruskal-Wallis tests. Overall and PCa survival were analyzed with Kaplan-Meier and Cox models adjusting for baseline variables. RESULTS: At diagnosis, Mexicans had more advanced stage, higher prostate-specific antigen and higher Gleason score while Cubans and Dominicans had more favorable PCa at diagnosis (all P<0.05). After a median follow up of 69 months, 20,317 men died, including 6,223 PCa deaths. Compared to Mexicans, Cubans (HR=1.22, 95%CI=[1.14-1.30]) and Puerto Ricans (HR=1.15 [1.08-1.22]) had worse overall survival while Dominicans (HR=0.76 [0.64-0.91]), South/Central Americans (HR=0.68, [0.65-0.72]) and NOS (HR=0.81 [0.78-0.84]) had better overall survival. Compared to Mexicans, Cubans (HR=1.08, [0.96-1.22]) and Puerto Ricans (HR=1.03, [0.92-1.15]) had similar PCa survival while Dominicans (HR=0.72, [0.53-0.98]), South/Central Americans (HR=0.67 [0.60-0.74]) and NOS (HR=0.68 [0.64-0.73]) had significantly better PCa survival. CONCLUSIONS: Among Hispanics in the United States, disparities in PCa characteristics and survival by country of origin exist, with Dominicans, South/Central Americans and Hispanic NOS having better PCa survival compared to Mexicans, Cubans and Puerto Ricans.
Publisher StatementPost print version of article may differ from published version. The final publication is available at springerlink.com; DOI:10.1038/s41391-018-0097-y
CitationDobbs, R. W., Malhotra, N. R., Abern, M. R., & Moreira, D. M. (2019). Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis. Prostate Cancer and Prostatic Diseases, 22(1), 159-167. doi:10.1038/s41391-018-0097-y