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Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain

journal contribution
posted on 20.07.2022, 18:32 authored by Rayyan Manwar, Juliana Benavides Lara, Ravi Prakash, Seyed Mohsen Ranjbaran, Kamran AvanakiKamran Avanaki
One of the key challenges in linear array transducer-based photoacoustic computed tomography is to image structures embedded deep within the biological tissue with limited optical energy. Here, we utilized a manually controlled multi-angle illumination technique to allow the incident photons to interact with the imaging targets for longer periods of time and diffuse further in all directions. We have developed and optimized a compact probe that enables manual changes to the angle of illumination while acquiring photoacoustic signals. The performance has been demonstrated and evaluated by imaging complex blood vessel mimicking phantoms in-vitro and sheep brain samples ex-vivo. For effective image reconstruction from the data acquired by multi-angle illumination method, we have utilized a method based on the extraction of maximum intensity. In both cases, multi-angle illumination has out-performed the conventional fixed angle illumination technique to improve the overall image quality. Specifically, extraction of the imaging targets located at greater axial depths was possible using this multi-angle illumination technique.

Funding

Transfontanelle photoacoustic imaging to study pathophysiology of neonatal brain injury | Funder: National Institutes of Health (National Institute of Biomedical Imaging and Bioengineering) | Grant ID: R01EB027769

3D neonatal Photoacoustic Tomography (3D-nPAT) to detect Hypoxic-Ischemic | Funder: National Institutes of Health (National Institute of Biomedical Imaging and Bioengineering) | Grant ID: R01EB028661

In vivo photoacoustic imaging of prefrontal cortex in rats undergoing fentanyl self-administration | Funder: National Institute on Drug Abuse | Grant ID: R21DA052657

History

Citation

Manwar, R., Lara, J. B., Prakash, R., Ranjbaran, S. M.Avanaki, K. (2022). Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain. Journal of Biophotonics, 15(6), e202200016-. https://doi.org/10.1002/jbio.202200016

Publisher

Wiley

Language

en

issn

1864-063X