Reactive Oxygen Species in Inflammation and Tissue Injury
journal contributionposted on 2015-08-13, 00:00 authored by Manish Mittal, Mohammad Rizwan Siddiqui, Khiem Tran, Sekhar P. Reddy, Asrar B. Malik
Abstract Reactive oxygen species (ROS) are key signaling molecules that play an important role in the progression of inflammatory disorders. An enhanced ROS generation by polymorphonuclear neutrophils (PMNs) at the site of inflammation causes endothelial dysfunction and tissue injury. The vascular endothelium plays an important role in passage of macromolecules and inflammatory cells from the blood to tissue. Under the inflammatory conditions, oxidative stress produced by PMNs leads to the opening of inter-endothelial junctions and promotes the migration of inflammatory cells across the endothelial barrier. The migrated inflammatory cells not only help in the clearance of pathogens and foreign particles but also lead to tissue injury. The current review compiles the past and current research in the area of inflammation with particular emphasis on oxidative stress-mediated signaling mechanisms that are involved in inflammation and tissue injury.
This work was supported by the AHA Midwest affiliate Postdoctoral fellowship (13POST16640000) to M.M., U.S. National Institutes of Health grants P01 HL77806, P01 HL 060678, R01 HL 045638, and R01 HL 090152 to A.B.M. and HL66109 and ES11863 to S.P.R.
Publisher StatementThis is a copy of an article published in the Antioxidants and Redox Signaling © 2014 Copyright Mary Ann Liebert, Inc.; Antioxidants and Redox Signaling is available online at: http://www.liebertonline.com.
PublisherMary Ann Liebert