University of Illinois at Chicago
20131014 Challenges in Cross Age Studies FINAL.pdf (203.48 kB)

Researching asthma across the ages: Insights from the National Heart, Lung, and Blood Institute's Asthma Network

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journal contribution
posted on 2016-02-08, 00:00 authored by Michael D. Cabana, Susan J. Kunselman, Sharmilee Nyenhuis, Michael E. Wechsler
Clinical asthma studies across different age groups, or ‘cross-age’ studies, can potentially offer insight into the similarities, differences and relationships between childhood and adult asthma. The National Institutes of Health Asthma Research Network (AsthmaNet) is unique and innovative in that it has merged pediatric and adult asthma research into one clinical research network. This combination enhances scientific exchange between pediatric and adult asthma investigators and encourages the application of ‘cross-age’ studies that involve participants from multiple age groups who are generally not studied together. The experience from AsthmaNet in the development of ‘cross-age’ protocols highlights some of the issues in the evaluation of cross-age research in asthma. The aim of this review is to summarize these challenges, including the selection of parallel, cross-age clinical interventions, identification of appropriate controls, measurement of meaningful clinical outcomes, as well as various ethical and logistical issues.


Support for this work was from the National Institutes of Health (HL098115). This publication was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number UL1 TR000004. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.





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