University of Illinois at Chicago
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Retinal nerve fibre layer thickness analysis in X-linked retinoschisis using Fourier-domain

journal contribution
posted on 2011-05-27, 00:00 authored by M.A. Genead, S. Pasadhika, G.A. Fishman
PURPOSE: To evaluate the presence of retinal nerve fibre layer (RNFL) defects in patients with X-linked retinoschisis (XLRS) using high-speed, high-resolution, Fourier domain OCT (FD-OCT). METHODS: Twenty-four patients with XLRS seen by the authors were enrolled in the study. All patients underwent a complete eye examination. FD-OCT was performed using Optovue technology. A quadrant of the RNFL was considered to be thinned if at least two of the four segments in the quadrant were reduced in thickness. RESULTS: The average age of the 24 patients in the study was 28.8+/-14.7 years. Thinning of the RNFL in one quadrant was seen in 10 patients (41.7%), and thinning in two or more quadrants was seen in 8 patients (33.3%). Thinning in the inferior quadrant was most commonly seen and was observed in 12 patients (50%), followed by the temporal quadrant in 8 patients (33.3%), nasal quadrant in 4 patients (16.7%), and the superior quadrant in 4 patients (16.7%). CONCLUSIONS: Among our 24 patients with XLRS, 15 patients (62.5%) showed a thinning of the RNFL in one or more quadrants in at least one eye and 9 patients (37.5%) in both eyes. High-speed, high-resolution FD-OCT may be useful to determine the presence of possible changes in RNFL thickness in patients with XLRS. Reductions in RNFL thickness in such patients could be relevant in their selection for future therapeutic trials.


Supported by funds from the Foundation Fighting Blindness, Owings Mills, Maryland; Grant Healthcare Foundation, Lake Forest, Illinois; NIH core grant EYO1792; and an unrestricted departmental grant from Research to Prevent Blindness.


Publisher Statement

Post print version of article may differ from published version. The original version is available through Nature Publishing Group at; DOI: 10.1038/eye.2009.53.


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