Lin Arthurs & Reilly BR Morphine ICX LI 2011 R2 text.pdf (399.54 kB)
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Role of the Insular Cortex in Morphine-Induced Conditioned Taste Avoidance

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journal contribution
posted on 26.05.2011, 00:00 by Jian-You Lin, Joe Arthurs, Steve Reilly
The present study investigated the role of the insular cortex (IC) in morphine-induced conditioned taste avoidance. The results of Experiment 1 revealed that IC lesions impaired taste neophobia, retarded acquisition of conditioned saccharin avoidance and apparently attenuated the magnitude of that response at asymptote. Using neurologically intact subjects, Experiment 2 established that a safe and familiar saccharin stimulus supports substantially weaker conditioned avoidance at asymptote than does a potentially dangerous and novel saccharin stimulus. This pattern of results does not support the hypothesis that IC lesions disrupt the learning mechanism responsible for morphine-induced conditioned taste avoidance. The data are, however, consistent with the hypothesis that IC lesions impair the perception of the danger and/or novelty of the taste stimulus.


This research was supported by grant DC06456 from the National Institute of Deafness and Other Communication Disorders.


Publisher Statement

NOTICE: this is the author’s version of a work that was accepted for publication in Brain Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain Research, [Vol 1384, (April 12, 2011)] DOI: 10.1016/j.brainres.2011.01.109. The original publication is available at







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