ars%2E2012%2E4669.pdf (244.62 kB)
Download fileS-Nitrosation: Current Concepts and New Developments
journal contribution
posted on 22.10.2013, 00:00 by Douglas D. Thomas, David Jourd’heuilThe S-nitrosation (also referred to as S-nitrosylation) of cysteine residues is an important post-translational
protein modification that regulates protein function and cell signaling. The original research articles and reviews
in this Forum cover important concepts in protein S-nitrosation and identify key developments and opportunities
for progress in this area. Defining the mechanisms by which S-nitrosothiols (RSNOs) may be formed
and decomposed in cells and tissues, the integration of the biological chemistry associated with nitric oxide (NO)
and other derivatives such as nitrite, and the development of new methodologies merging proteomics and
direct quantitation are all key issues that we believe would require detailed attention. Antioxid. Redox Signal. 17,
934–936.