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Selenium-binding protein 1 as a tumor suppressor and a prognostic indicator of clinical outcome

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journal contribution
posted on 11.04.2016, 00:00 by Wancai Yang, Alan M Diamond
Selenium is a trace element that plays a critical role in physiological processes and cancer prevention, whose functions may be through its effects on selenium-containing proteins. Selenium-binding protein 1 (SBP1) is a member of an unusual class of selenium-containing proteins that may function as a tumor suppressor in multiple cancer types and whose levels have been shown to be lower in cancers as compared to corresponding normal tissues. This review is intended to summarize recent advances in gaining an understanding of the significance of SBP1 in carcinogenesis, and suggest that SBP1 could be developed as a potential biomarker for cancer progression and prognosis.


This work is sponsored in part by the grant from the Nature Science Foundation of China (grant # 81272251 and 91229115 to W. Yang) , the startup fund from Xinxiang Medical University (to W .Yang), China and by a grant from the National Institutes of Health (Grant # RO1CA127943 to A.M. Diamond).


Publisher Statement

© Yang and Diamond; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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