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Spontaneous tumor lysis syndrome in the setting of Candida albicans Fungemia
journal contributionposted on 2023-05-17, 16:47 authored by Anthony Acosta, Samantha Venkatesh, Zane ElfessiZane Elfessi
Tumor Lysis Syndrome (TLS) is a metabolic emergency seen in patients who receive cytotoxic chemotherapy and can result in significant morbidity and mortality, especially in those patients with high tumor burden. Spontaneous tumor lysis syndrome (STLS) occurs in patients without preceding chemotherapy but may occur in the setting of glucocorticoid administration. We present a case of a 75-year-old male with a history of myelodysplastic syndrome who presented with shortness of breath and developed acute renal failure due to tumor lysis syndrome, likely triggered by candidemia. To our knowledge, this is the first known case of STLS in a patient with high tumor burden who did not receive corticosteroids but likely developed this condition in the setting of infection.
CitationAcosta, A., Venkatesh, S.Elfessi, Z. (2023). Spontaneous tumor lysis syndrome in the setting of Candida albicans Fungemia. The American Journal of Emergency Medicine, 67, 195.e5-195.e6. https://doi.org/10.1016/j.ajem.2023.03.023
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32 Biomedical and Clinical Sciences3202 Clinical SciencesHematologyCancer2 Aetiology7 Management of diseases and conditions7.3 Management and decision making2.1 Biological and endogenous factorsMaleHumansAgedTumor Lysis SyndromeCandida albicansFungemiaAcute Kidney InjuryAcute myeloid leukemiaMyelodysplastic syndromeTumor lysis syndromeEmergency & Critical Care Medicine3202 Clinical sciencesClinical Sciences