The Association of Previous Prostate Biopsy-Related Complications and the Type of Complication with Patient Compliance with Re-Biopsy Scheme
journal contributionposted on 16.11.2018, 00:00 by Logan S. Schwarzman, Michael R. Abern, Daniel F. Garvey, Gerald L. Andriole, Stephen J. Freedland, Daniel M. Moreira
Introduction: Prostate biopsy complications have important consequences that may affect patient compliance with re-biopsy schemes; however, this has not been studied in earnest. Thus, we evaluated whether previous prostate biopsy-related complications and the type of complication were associated with repeat prostate biopsy compliance in a clinical trial with study-mandated systematic biopsies. Materials and Methods: Retrospective analysis of 4,939 men ages 50-75 who underwent a 2-year prostate biopsy and were recommended to undergo the 4-year prostate re-biopsy in the Reduction by Dutasteride of prostate cancer Events (REDUCE) study. The analyzed biopsy complications were: hematuria, urinary tract infection (UTI), acute urinary retention (AUR) and hematospermia. Results: A total of 260 (5.3%) men had a 2-year prostate biopsy-related complication, including 180 (3.6%) hematuria, 36 (0.7%) UTI, 26 (0.5%) AUR, and 102 (2.1%) hematospermia. A total of 474 (9.6%) men were noncompliant with the 4-year re-biopsy. In univariable analysis, any previous complication (OR=1.56, 95%CI=1.08-2.24, P=0.018), UTI (OR=2.72, 95%CI=1.23-6.00, P=0.013), AUR (OR=4.24, 95%CI=1.83-9.81, P=0.016) and hematospermia (OR=1.78, CI=1.03-3.06, P=0.037) were associated with re-biopsy noncompliance. Hematuria was not associated with re-biopsy noncompliance (OR=1.19, CI=0.74-1.91, P=0.483). Results were unchanged in multivariable analysis (any complication: OR=1.65, 95%CI=1.08-2.26, P=0.018; UTI: OR=2.62, 95%CI=1.07-3.21, P=0.029; AUR: OR=4.51, 95%CI=1.93-10.54, P=0.001; hematospermia: OR=1.85, 95%CI=1.07-3.21, P=0.029; hematuria: OR=1.19, 95%CI=0.74-1.93, P=0.472). Conclusion: In men undergoing repeat prostate biopsy, a previous biopsy-related complication and the type of complication were associated with lower compliance with re-biopsy schemes. Patients experiencing biopsy-related complications are ideal candidates to receive interventions regarding the importance of prostate re-biopsy to prevent noncompliance.