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The Essential Medicinal Chemistry of Cannabidiol (CBD)

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posted on 25.03.2021, 19:13 by KM Nelson, J Bisson, G Singh, JG Graham, SN Chen, JB Friesen, JL Dahlin, M Niemitz, MA Walters, GF Pauli
© 2020 American Chemical Society. All rights reserved. This Perspective of the published essential medicinal chemistry of cannabidiol (CBD) provides evidence that the popularization of CBD-fortified or CBD-labeled health products and CBD-associated health claims lacks a rigorous scientific foundation. CBD's reputation as a cure-all puts it in the same class as other "natural" panaceas, where valid ethnobotanicals are reduced to single, purportedly active ingredients. Such reductionist approaches oversimplify useful, chemically complex mixtures in an attempt to rationalize the commercial utility of natural compounds and exploit the "natural" label. Literature evidence associates CBD with certain semiubiquitous, broadly screened, primarily plant-based substances of undocumented purity that interfere with bioassays and have a low likelihood of becoming therapeutic agents. Widespread health challenges and pandemic crises such as SARS-CoV-2 create circumstances under which scientists must be particularly vigilant about healing claims that lack solid foundational data. Herein, we offer a critical review of the published medicinal chemistry properties of CBD, as well as precise definitions of CBD-containing substances and products, distilled to reveal the essential factors that impact its development as a therapeutic agent.

Funding

Botanical Dietary Supplements for Women's Health

National Center for Complementary and Integrative Health

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Center for Natural Product Technologies at UIC (CeNAPT)

National Center for Complementary and Integrative Health

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History

Publisher Statement

This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

Citation

Nelson, K. M., Bisson, J., Singh, G., Graham, J. G., Chen, S. N., Friesen, J. B., Dahlin, J. L., Niemitz, M., Walters, M. A.Pauli, G. F. (2020). The Essential Medicinal Chemistry of Cannabidiol (CBD). Journal of Medicinal Chemistry, 63(21), 12137-12155. https://doi.org/10.1021/acs.jmedchem.0c00724

Publisher

American Chemical Society (ACS)

Language

en

issn

0022-2623

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