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The Essential Medicinal Chemistry of Curcumin

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journal contribution
posted on 25.03.2021, 19:02 by KM Nelson, JL Dahlin, J Bisson, J Graham, GF Pauli, MA Walters
© 2017 American Chemical Society. Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.

Funding

Center for Natural Product Technologies at UIC (CeNAPT)

National Center for Complementary and Integrative Health

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Citation

Nelson, K. M., Dahlin, J. L., Bisson, J., Graham, J., Pauli, G. F.Walters, M. A. (2017). The Essential Medicinal Chemistry of Curcumin. Journal of Medicinal Chemistry, 60(5), 1620-1637. https://doi.org/10.1021/acs.jmedchem.6b00975

Publisher

American Chemical Society (ACS)

Language

en

issn

0022-2623

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