REV Mehta HIV SC at 72m AIDS FINAL 1-10-13 rev 3-4-13 rev 5-10-13 FINAL.pdf (368.01 kB)
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The Long Term Efficacy of Medical Male Circumcision against HIV Acquisition

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journal contribution
posted on 29.03.2016, 00:00 by Supriya D. Mehta, Stephen Moses, Kawango Agot, Elijah Odoyo-June, Hong Li, Ian Maclean, Donald Hedeker, Robert C. Bailey
BACKGROUND:: In three randomized trials, medical male circumcision (MMC) reduced HIV acquisition in heterosexual men in sub-Saharan Africa by approximately 60%, after 21-24 months of follow-up. We estimated the 72-month efficacy of MMC against HIV among men retained in the Kisumu randomized trial, where HIV acquisition was reduced by 60% after 24 months. METHODS:: From 2002-2005, 2,784 men aged 18-24 were enrolled and randomized 1:1 to immediate circumcision or control. At trial end in December 2006, control men were offered free circumcision. Follow-up continued through September 2010. Cox proportional hazards regression incorporating stabilized inverse probability of treatment and censoring weights generated through marginal structural modeling, was used to account for potential time-varying confounding and censoring to estimate the efficacy of MMC on HIV risk. RESULTS:: The cumulative 72-month HIV incidence was 7.21% [95% CI: 5.98-8.68%]: 4.81% among circumcised men, 11.0% among uncircumcised men. The crude hazard ratio (HR) of HIV seroconversion for circumcised vs. uncircumcised men was 0.38 [95% CI: 0.26-0.55]. In weight-adjusted Cox regression, the HR was 0.42 [95% CI: 0.26-0.66]. CONCLUSIONS:: The efficacy of MMC was sustained at 58% at 72 months, similar to overall findings of the three trials under conditions of randomization. These findings provide an estimate of the long-term efficacy of circumcision against HIV acquisition. Our results support programmatic scale-up recommendations that are based on assumptions of sustained efficacy.

Funding

This trial was supported by grant number AI50440 from the NIAID, Division of AIDS, NIH; and by grant number HCT 44180 from the Canadian Institutes of Health Research. RCB was partially supported by the Chicago Developmental Center for AIDS Research (D-CFAR), an NIH funded program (P30 AI 082151).

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Publisher Statement

Post print version of article may differ from published version. The final publication is available at www.lww.com/; DOI:10.1097/01.aids.0000432444.30308.2d

Publisher

Lippincott, Williams & Wilkins

Language

en_US

issn

1473-5571

Issue date

01/07/2013

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