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The microRNA-183 cluster: the family that plays together stays together.

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journal contribution
posted on 12.05.2016, 00:00 by S Dambal, M Shah, B Mihelich, L Nonn
The microRNA (miR)183 cluster, which is comprised of miRs-183, -96 and -182, is also a miR family with sequence homology. Despite the strong similarity in the sequences of these miRs, minute differences in their seed sequences result in both overlapping and distinct messenger RNA targets, which are often within the same pathway. These miRs have tightly synchronized expression during development and are required for maturation of sensory organs. In comparison to their defined role in normal development, the miR-183 family is frequently highly expressed in a variety of non-sensory diseases, including cancer, neurological and auto-immune disorders. Here, we discuss the conservation of the miR-183 cluster and the functional role of this miR family in normal development and diseases. We also describe the regulation of vital cellular pathways by coordinated expression of these miR siblings. This comprehensive review sheds light on the likely reasons why the genomic organization and seeming redundancy of the miR-183 family cluster was conserved through 600 million years of evolution.

Funding

National Institutes of Health [CA R01 CA166588 Nonn]. Funding for open access charge: NIH [R01 CA166588]; Research Open Access Publishing (ROAAP) Fund of the University of Illinois at Chicago.

History

Publisher Statement

This is the copy of an article published in Nucleic Acids Research© 2015 Oxford University Press.

Publisher

Oxford University Press

issn

0305-1048

Issue date

03/09/2015

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