University of Illinois at Chicago
Three-dimensional spectral...... intravitreal parasite.pdf (1.83 MB)

Three-dimensional spectral domain optical coherence tomography and light microscopy of an intravitreal parasite

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journal contribution
posted on 2016-09-12, 00:00 authored by A. A. Khanifar, M. J. Espiritu, J. S. Myung, G. D. Aaker, A. N. Schuetz, D. J. D’Amico, R. V. P. Chan
Background: Various imaging modalities play a role in diagnosing parasitic infections of the eye. We describe the spectral domain optical coherence tomography (SD-OCT) findings of an intravitreal parasite with subsequent evaluation by light microscopy. Findings: This is a case report of a 37-year-old Ecuadorian man who presented with uveitic glaucoma and a new floater in his left eye for 1 week’s duration. Full ophthalmic examination revealed an intravitreal parasite. Color fundus photography, fluorescein angiography (FA), ocular ultrasonography (US), and SD-OCT were performed. The parasite was removed via 23-gauge pars plana vitrectomy and sent to pathology for evaluation. Color fundus photography and ocular ultrasonography demonstrated an elongated foreign body within the vitreous above the retina. FA demonstrated minimal vascular changes in the vicinity of the parasite. SD-OCT was utilized to visualize the parasite and to create a three-dimensional (3D) image. The parasite was determined to be most consistent with Gnathostoma spp. by morphologic analysis. Conclusions: This is the first reported case of SD-OCT of an intravitreal parasite with corresponding evaluation by pathology. SD-OCT allows non-invasive, high-resolution visualization and 3D reconstruction of parasitic anatomy which may help establish tomographic criteria for species identification.


Support was provided by the St. Giles Foundation (RVPC), Departmental Grant from Research to Prevent Blindness (RVPC, AAK, JSM, GDA, MJE, DJD).


Publisher Statement

This is a copy of an article published in the Journal of Ophthalmic Inflammation and Infection. © 2015, Khanifar et al.


Springer Verlag


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