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Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
journal contributionposted on 2022-11-01, 22:01 authored by Heather M Brockway, Suhas G Kallapur, Irina BuhimschiIrina Buhimschi, Catalin BuhimschiCatalin Buhimschi, William AckermanWilliam Ackerman, Louis J Muglia, Helen N Jones
Preterm birth (PTB) is leading contributor to infant death in the United States and globally, yet the underlying mechanistic causes are not well understood. Histopathological studies of preterm birth suggest advanced villous maturity may have a role in idiopathic spontaneous preterm birth (isPTB). To better understand pathological and molecular basis of isPTB, we compared placental villous transcriptomes from carefully phenotyped cohorts of PTB due to infection or isPTB between 28-36 weeks gestation and healthy term placentas. Transcriptomic analyses revealed a unique expression signature for isPTB distinct from the age-matched controls that were delivered prematurely due to infection. This signature included the upregulation of three IGF binding proteins (IGFBP1, IGFBP2, and IGFBP6), supporting a role for aberrant IGF signaling in isPTB. However, within the isPTB expression signature, we detected secondary signature of inflammatory markers including TNC, C3, CFH, and C1R, which have been associated with placental maturity. In contrast, the expression signature of the gestational age-matched infected samples included upregulation of proliferative genes along with cell cycling and mitosis pathways. Together, these data suggest an isPTB molecular signature of placental hypermaturity, likely contributing to the premature activation of inflammatory pathways associated with birth and providing a molecular basis for idiopathic spontaneous birth.
CitationBrockway, H. M., Kallapur, S. G., Buhimschi, I. A., Buhimschi, C. S., Ackerman, W. E., Muglia, L. J.Jones, H. N. (2019). Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births. PLOS ONE, 14(11), e0225062-. https://doi.org/10.1371/journal.pone.0225062
PublisherPublic Library of Science (PLoS)
CategoriesNo categories selected
Preterm, Low Birth Weight and Health of the NewbornContraception/ReproductionInfectious DiseasesPediatricInfant MortalityGeneticsPerinatal Period - Conditions Originating in Perinatal Period2.1 Biological and endogenous factorsReproductive health and childbirth3 Good Health and Well BeingAdultDisease SusceptibilityFemaleGene Expression ProfilingGene Expression RegulationHumansMaleMitosisPremature BirthReproducibility of ResultsSignal TransductionTerm BirthTranscriptomeGeneral Science & Technology