mRNA Localization of ASXL2
journal contributionposted on 30.07.2019, 00:00 authored by Yanyang Li, Andrea L. McGinley
Congenital heart disease (CHD) is the most common birth defect. However, the etiology for the majority of CHD cases have been unknown. Our lab identified a chromatin factor, Additional Sex Combs-Like 2 (ASXL2), as a novel regulator of cardiovascular development. ASXL2 fetuses display congenital heart malformations. To support the notion that ASXL2 plays important roles in cardiovascular development, I conducted whole mount in situ hybridization experiment to examine the distribution of ASXL2 mRNA in mouse embryo at embryonic day 10.5. It resulted in a surprisingly beautiful pattern of high expression level of ASXL2 in the heart and somites. The image in the submission was captured by Andrea using a dissection microscope.