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mRNA Localization of ASXL2

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journal contribution
posted on 30.07.2019, 00:00 by Yanyang Li, Andrea L. McGinley
Congenital heart disease (CHD) is the most common birth defect. However, the etiology for the majority of CHD cases have been unknown. Our lab identified a chromatin factor, Additional Sex Combs-Like 2 (ASXL2), as a novel regulator of cardiovascular development. ASXL2 fetuses display congenital heart malformations. To support the notion that ASXL2 plays important roles in cardiovascular development, I conducted whole mount in situ hybridization experiment to examine the distribution of ASXL2 mRNA in mouse embryo at embryonic day 10.5. It resulted in a surprisingly beautiful pattern of high expression level of ASXL2 in the heart and somites. The image in the submission was captured by Andrea using a dissection microscope.


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Biological Sciences; Finalist; Copyright 2014, Yanyang Li & Andrea L. McGinley. Used with permission. For more information, contact the Graduate College at



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