Lloyd_Mark.pdf (2.69 MB)
0/0

An Evolutionary and Ecological Investigation of Cancer

Download (2.69 MB)
thesis
posted on 01.07.2016 by Mark C. Lloyd
I propose to investigate how Darwinian dynamics, as defined as the simultaneous evolution of populations and strategies on a continuous adaptive landscape, applies to cancer [Vincent 2005]. I am interested in investigating how and why intratumoral spatial heterogeneity of cancer cell populations, although sometimes initiated by random mutations, must be governed by identifiable Darwinian dynamics [Santos 2006, Gillies 2012]. My central hypothesis is that the physical morphology of cancer cells, which can be observed and quantified, provides deep insight into adaptations governed by variations in selection forces within local microenvironments. Furthermore, I submit that an evaluation of the evolution of cancer’s intratumoral heterogeneity is not chaotic or unpredictable, but can be understood by identifying regional variations in selection forces and adaptive strategies [Lloyd 2014].

History

Advisor

Brown, Joel S.

Department

Biological Sciences

Degree Grantor

University of Illinois at Chicago

Degree Level

Doctoral

Committee Member

Mason-Gamer, Roberta J. Minor, Emily S. Gatenby, Robert A. Bui, Marilyn M.

Submitted date

2016-05

Language

en

Issue date

01/07/2016

Exports

Categories

Exports