University of Illinois at Chicago
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Association of Neuroinflammation with Electroencephalographic Consequences of Subarachnoid Hemorrhage

thesis
posted on 2023-05-01, 00:00 authored by Joseph R Geraghty
Subarachnoid hemorrhage (SAH) is a form of hemorrhagic stroke that poses a serious public health concern due to its high mortality rate and long-term complications including neurobehavioral impairment and the development of lifelong epilepsy. One mechanism underlying these deficits is the prominent neuroinflammatory response observed throughout the brain after SAH and its potential role in driving epileptogenesis. While the development of abnormal electroencephalographic (EEG) activity in patients suffering from SAH is a well-documented epidemiological observation, to date no animal models have been developed to study these particular consequences of SAH. Here, we identify novel inflammatory biomarkers in patients with SAH, develop novel methods for analyzing EEG changes in established animal models of epilepsy, and then apply these methods for the first time in an animal model of SAH. Finally, we characterize the relationship between intracranial hemorrhage, activation of microglia, and modulate these inflammatory responses with the immunomodulatory agent fingolimod. Investigating the role of immune and inflammatory responses within the central nervous system after SAH offers the potential for the discovery of novel mechanistic and therapeutic targets which may have long-lasting benefits in survivors of SAH.

History

Advisor

Loeb, Jeffrey ATestai, Fernando D

Chair

Lazarov, Orly

Department

Neurology & Rehabilitation

Degree Grantor

University of Illinois at Chicago

Degree Level

  • Doctoral

Degree name

PhD, Doctor of Philosophy

Committee Member

Larson, John Lutz, Sarah Amin-Hanjani, Sepideh

Submitted date

May 2023

Thesis type

application/pdf

Language

  • en

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