CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis

In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic homeostasis. Specifically, loss of a Forkhead box class O1 transcription factor (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a sexually-dimorphic manner in an CX3CR1 FoxO1-KO in vivo model.