Conjugation of Zwitterionic and Cationic Peptides to Lipid and Polymer for Gene Delivery

This dissertation focuses on the new materials that we established by the chemical conjugation between the peptides and the corresponding backbones. In total, we focus on 3 types of conjugates mainly. They are the zwitterionic peptide (EK)x pair lipid DSPE conjugates, THE DSPE-(EK)x, the cationic ionizable peptide RxHy lipid DSPE conjugates, the DSPE-RxHyC, and the cationic ionizable peptide RxHyC polysaccharide sugar mannan conjugates, the RxHyC-mannan. Such three different conjugates focus on different functionalities, with predesigned peptide sequences and the backbone to achieve desired results for siRNA delivery.