Conversion of Cannabidiol to Tetrahydrocannabinol: an Analysis of Dispensary Products

This study employed liquid chromatography to examine cannabinoid quantities in edible candies obtained from dispensaries. The objective was to measure the presence of tetrahydrocannabinol (THC) and investigate its potential conversion from cannabidiol (CBD) in products containing CBD. A heat study was conducted on cannabidiol powder at cooking temperatures, revealing the breakdown of cannabidiol and an increase in THC levels. Dispensary products, including lollipops, chocolates, caramels, and gummies, underwent analysis using Triple Quad LC/MS. None of the samples exceeded the regulatory THC limit of 0.3%. Notably, products containing CBD and cannabigerol (CBG) displayed higher reported concentrations of THC. CBG, serving as the parent compound for CBD and THC formulation in cannabis plants, suggests that products with multiple THC precursors, like CBD and CBG, may undergo enhanced conversion when exposed to high heat or acidic conditions. This study highlights the importance of understanding cannabinoid compounds in manufactured products and the significance of accurate testing in forensic science for legal cases. Overcoming historical limitations, the research contributes to the knowledge surrounding cannabis and its implications in the medical field.