University of Illinois at Chicago
DREYER-THESIS-2017.pdf (2.02 MB)

Design, Fabricate, and Test an in vitro System to Investigate Therapeutic Hypothermia in Porcine Eyes

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posted on 2017-11-01, 00:00 authored by Samuel Dreyer
Traumatic eye injuries are 4th in volume behind traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), and hearing loss for serious injuries among active duty personnel. An injury to the eye is a precursor for a long-term visual disability including blindness or loss of visual acuity and is often caused by ischemia to the retinal cells responsible for vision. Therapeutic hypothermia has been shown to have a neuroprotective effect. If the eye can be cooled, it may be possible to mitigate this damage. The eye can be treated by local hypothermia, avoiding the risks and slow implementation associated with systemic hypothermia. The main goal of this project was to reduce the temperature of the posterior pole of the eye and proximal optic nerve by contacting the anterior surface of the eye. In this thesis, a compact solid-state eye cooler is proposed to address the significant need for a portable, field-deployable, robust means of achieving and maintaining therapeutic cooling of eye tissues following traumatic injury. In clinical use, the objective is to develop a device that will be applied as soon as possible after injury, during transport from the field, and while the patient is awaiting definitive therapy in the hospital.



Hetling, John


Hetling, John



Degree Grantor

University of Illinois at Chicago

Degree Level

  • Masters

Committee Member

Kotche, Miiri Roth, Steve

Submitted date

August 2017

Issue date


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