Design, Synthesis, and Characterization of Zwitterionic Materials for Biomedical Applications

In this dissertation, we developed a zwitterionic materials platform to integrated all desired properties and easily adapted these materials for a broad range of applicaions. Firstly, a pH-responsive zwitterionic material was synthesized with charge-swichability, controllable surface property, buffering ability at acid condition and chelating capability with multi-valent metal ions, which can be potentially used for wound healing applications. Secondly, a zwitterionic polyurethane platform with tunable bulk and surface properties were developed. These zwitterionic polyurethanes demonstrated excellent properties to resist protein adsorption, mammalian cells attachment and biofilm formation, which can be a promising material for implantable biomedical devices.