Development of New Metal-Catalyzed Divalent Atom Transfer Reactions

The Driver group is known for the development of transition metal catalyzed C–N bond formation to construct N-heterocycles. As our group's research interests studying the reactivity of metal divalent catalytic intermediates, my thesis research has been focused on exploiting different reactivity patterns embedded in metal N-aryl nitrene and electron-rich metal aryl carbenes. In addition to developing new methods of N-atom and C-atom transfer reactions, I also used the metal-catalyzed C–N bond formation strategy to create novel small molecule NAMPT inhibitors as potential therapeutics for the treatment of pulmonary arterial hypertension (PAH).