Endothelium in Dyslipidemia

OxLDL is known to play a role in endothelial dysfunction. In this paper, an investigation was done to determine the effect of oxLDL on angiogenesis of human aortic endothelial cells by investigating the proliferative and migratory effects. In this paper, it was determined that oxLDL-induced proliferation was activated via the Rho/Rock/AKT pathway while oxLDL-induced migration is activated by a different pathway. Also, in this paper, an investigation on endothelial cholesterol loading and depletion was done. It was determined that cholesterol loading has inhibitory effects on proliferation and that cholesterol decreases vasodilation by causing Kir2.1 to become dysfunctional.