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Evaluation of Plasma Lipoprotein Profiles in a Mediterranean Diet Intervention

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posted on 01.08.2020, 00:00 authored by Aimee J Karstens
Nonpharmacological interventions that target modifiable risk factors such as obesity, diet, sedentary lifestyle, and downstream metabolic correlates (e.g., dyslipidemia) are increasingly being investigated to prevent Alzheimer's disease (AD). The plasma lipoprotein profile is age, APOE-genotype, sex, and modifiable risk dependent.The current study used a precision medicine approach to study a potential AD biomarker and clinical intervention through a model of risk. Plasma samples were leveraged from a Mediterranean diet randomized controlled trial in a sample of female obese older adults who are predominately African American. Plasma lipoprotein profiles were quantified from pre- and post-intervention plasma samples using size exclusion chromatography and cholesterol assays. Our results indicated notable eulipidemic shifts in the plasma lipoprotein profile. There was an effect of decreased weight and adiposity on eulipidemic shifts. APOE signature profiles and patterns of lipoprotein remodeling were evident. Future work will further establish the plasma lipoprotein profiles as a biomarker with further examination of lipid/protein content and associations with cognition.

History

Advisor

Langenecker, Scott ALaDu, Mary Jo

Chair

Maki, Pauline

Department

Psychology

Degree Grantor

University of Illinois at Chicago

Degree Level

Doctoral

Degree name

PhD, Doctor of Philosophy

Committee Member

Tussing-Humphreys, Lisa Pliskin, Neil Fitzgibbon, Marian

Submitted date

August 2020

Thesis type

application/pdf

Language

en

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