Exploration of Molecular Mechanisms of Aulosirazole and Wheldone for High-Grade Serous Ovarian Cancer

Chapter I is a summary of the project that generated this work. It provides background information and emphasizes the importance of this thesis. Chapter II is largely a summary of methods and materials behind the data presented in subsequent chapters. Chapter III describes the mechanism and action of aulosirazole in ovarian cancer. A majority of Chapter II and Chapter III is adapted from a published manuscript on aulosirazole for which I am the first author and main driver of research. Chapter IV presents data on the discovery of molecular mechanism of wheldone, which is unpublished as of the submission of this manuscript. Chapter V contains a discussion of these results and future directions to explore. Appendices contain supplemental data and approvals.