Gamma-carbon–carbon Bond Formation Towards Synthesis of Natural Products

Synthetic attempts towards natural product synthesis indicate a deficiency in the synthetic means to achieve gamma-carbon–carbon bond formation. The gamma-carbon–carbon bond exists in numerous natural products and pharmaceutical targets. To address these limitations, new synthetic transformations are developed. To address the challenge of accessing gamma-alkyl and gamma-alkenyl groups, an iron-catalyzed, structurally divergent gamma-alkylation reaction between alpha,alpha.alpha-trihaloalkyl substrates and silyl dienol ethers is discovered. To address the challenge of accessing gamma-arylation, a nickel-catalyzed reaction between aryl boronic acids and silyl dienol ethers.