VENTURINI-THESIS-2021.pdf (13.39 MB)
Download fileHigh-Throughput Hydrostatic Pressure Waveform Control
thesis
posted on 2021-12-01, 00:00 authored by Giulia VenturiniHydrostatic pressure (HP) regulates the functioning of a significant number of organs and
tissues in the human body. At a cellular level, it is involved in the regulation of proliferation,
di↵erentiation, migration and apoptosis. Non-physiological values of hydrostatic pressure can
compromise these processes, leading to the development of severe diseases, like heart pathologies
due to hypertension.
Due to its impact on cell behavior, over the past two decades, many microfluidic devices
have been developed to study HP and its e↵ects on cells. However, most of the devices show a
significant drawback: they are low-throughput systems.
Our project aims to solve this issue by proposing a device that incorporates the 96 well
plate, commonly used in biological applications, with a high-throughput pressure delivery system.
Our setup permits to simultaneously stimulate cells with twelve completely unique pressure
conditions. Moreover, it is able to mimic real pressure waveforms, in terms of pressure
range, morphology and frequency, through a PID-controlled, proportional solenoid valve control
system.
History
Advisor
Eddington, David T.Chair
Eddington, David T.Department
BioengineeringDegree Grantor
University of Illinois at ChicagoDegree Level
- Masters
Degree name
MS, Master of ScienceCommittee Member
Papautsky, Ian Dubini, Gabriele AngeloSubmitted date
December 2021Thesis type
application/pdfLanguage
- en