Pattabiraman_Goutham.pdf (4.85 MB)
Innate Apoptotic Immunity: Characterization of Macrophage Responses
thesisposted on 2014-02-24, 00:00 authored by Goutham Pattabiraman
About 10^11 cells die daily by apoptosis (programmed physiological cell death) in the human body. Cells dying by apoptosis are rapidly engulfed and digested by their neighbors or by professional phagocytes in a process of phagocytosis, such that we are barely able to detect apoptotic cells in vivo normally. During the process of apoptosis, cells acquire a distinct “gain-of-function” trait which triggers a milieu of signaling events in the neighboring interacting cells, leading to an immunosuppressive (especially anti-inflammatory) state. While the mechanisms of apoptosis and those of clearance of effete cells have been studied extensively, those related to this gain-of-function accompanying apoptosis are much less understood. Perhaps the ultimate objective of the apoptotic process, along with the efficient elimination of inappropriate and non-functional cells, is to restore a physiological (non-inflammatory, “calm”) setting. Understanding this immunosuppressive activity of apoptotic cells, which we have termed “Innate Apoptotic Immunity (IAI), is the focus of this thesis.
DepartmentMicrobiology and Immunology
Degree GrantorUniversity of Illinois at Chicago
Committee MemberMcLachlan, Alan Walden, William Freitag, Nancy Raychaudhuri, Pradip Levine, Jerrold