Mansour_Ibrahim.pdf.pdf (283.05 kB)
0/0

Left Ventricular Strain Predicts Heart Failure Admissions in African Americans with Heart Failure

Download (283.05 kB)
thesis
posted on 16.02.2016 by Ibrahim N. Mansour
Left ventricular global longitudinal strain (LV GLS) is a sensitive measure of LV mechanics that has been correlated with adverse events in patients with heart failure. Previous studies have included few African American (AA) patients. We enrolled 207 AA adults, age 56 ± 14.5 years, with New York heart Association (NYHA) class I through III HF on optimal guideline-directed medical therapy (GDMT) from the University of Illinois HF clinic between November 2001 and February 2014. LV GLS was assessed by velocity vector imaging using 2, 3 and 4-chamber views. Patients were followed for HF admissions and death for 3 ± 3.0 years. LV GLS value of -7.95 was used as the optimal cutoff point that maximizes sensitivity and specificity LV GLS >-7.95% was significantly associated with higher all-cause mortality and HF admissions in Kaplan-Meier survival curves (log-rank P<0.001). After incorporated in a multivariate Cox proportional hazard models, GLS > -7.95% was found to be an independent predictor of all-cause mortality (HR=4.20; 95% CI 1.14-15.56; p =0.014) and HF admissions (HR3.86; 95% CI 1.38-10.77; p =0.010). In AA patients with chronic stable HF on GDMT, more impaired LV GLS (>-7.95%) is a strong and independent predictor of long-term all-cause mortality and HF admission.

History

Advisor

Zwanziger, Jack

Department

Health Policy and Administration

Degree Grantor

University of Illinois at Chicago

Degree Level

Masters

Committee Member

Stamos, Thomas Kansal, Mayank

Submitted date

2015-12

Language

en

Issue date

16/02/2016

Exports

Categories

Exports