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Mechanisms of Biological Functions Through Polymer Deep Sampling: Protein Gating and Chromatin Folding

thesis
posted on 01.05.2021, 00:00 by Alan Jerome Perez-Rathke
We develop probabilistic models of folded biopolymers which allow detailed insight into mechanisms governing many biological processes. Our computational models complement existing experimental techniques which provide valuable measurements but do not provide 3-D structural details that may be key to understanding the underlying biological processes. We demonstrate how the deep probabilistic sampling methodology developed here can be used to discern important properties of both chromatin and protein.

History

Advisor

Liang, Jie

Chair

Liang, Jie

Department

Bioengineering

Degree Grantor

University of Illinois at Chicago

Degree Level

Doctoral

Degree name

PhD, Doctor of Philosophy

Committee Member

Dai, Yang Ma, Ao Berger-Wolf, Tanya Kenter, Amy

Submitted date

May 2021

Thesis type

application/pdf

Language

en