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Mechanisms of Biological Functions Through Polymer Deep Sampling: Protein Gating and Chromatin Folding
thesisposted on 2021-05-01, 00:00 authored by Alan Jerome Perez-Rathke
We develop probabilistic models of folded biopolymers which allow detailed insight into mechanisms governing many biological processes. Our computational models complement existing experimental techniques which provide valuable measurements but do not provide 3-D structural details that may be key to understanding the underlying biological processes. We demonstrate how the deep probabilistic sampling methodology developed here can be used to discern important properties of both chromatin and protein.