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Novel Imaging Mass Spectrometry Techniques to Capture Chemical Exchange in Models of Ovarian Cancer and Symbiosis
thesisposted on 01.08.2020, 00:00 by Katherine E Zink
This dissertation explores existing and novel uses of imaging mass spectrometry to investigate chemical exchange in two distinct model systems. IMS was used to detect a specific interaction between a fallopian tube epithelium-derived protein and a small molecule neurotransmitter from ovarian tissue in an ovarian cancer model. Additionally, IMS was used to analyze a host-microbe symbiosis both in vitro and in situ to capture a small molecule influencing host colonization.