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Synthesis, Photoaffinity Labeling Studies, Biological Evaluation of Photoreactive Probes for HDAC2 and 8

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posted on 25.02.2016 by Aditya S. Vaidya
Histone deacetylases are validated targets for multiple therapeutic applications. Existing histone deacetylase inhibitors have a zinc chelating group, which limits their use due to metabolic instability.The presented work deals with exploration of novel binding sites in histone deacetylase 2 and 8 with photoreactive ligands for the design of histone deacetylase inhibitors without a zinc chelating group.

History

Advisor

Petukhov, Pavel A.

Department

Medicinal Chemistry and Pharmacognosy

Degree Grantor

University of Illinois at Chicago

Degree Level

Doctoral

Committee Member

Thatcher, Gregory R. Bruzik, Karol S. van Breemen, Richard B. Garcia-Martinez, Jesus

Submitted date

2013-12

Language

en

Issue date

24/02/2014

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