Vaidya_Aditya.pdf (10.61 MB)
Synthesis, Photoaffinity Labeling Studies, Biological Evaluation of Photoreactive Probes for HDAC2 and 8
thesis
posted on 2016-02-25, 00:00 authored by Aditya S. VaidyaHistone deacetylases are validated targets for multiple therapeutic applications. Existing histone deacetylase inhibitors have a zinc chelating group, which limits their use due to metabolic instability.The presented work deals with exploration of novel binding sites in histone deacetylase 2 and 8 with photoreactive ligands for the design of histone deacetylase inhibitors without a zinc chelating group.
History
Advisor
Petukhov, Pavel A.Department
Medicinal Chemistry and PharmacognosyDegree Grantor
University of Illinois at ChicagoDegree Level
- Doctoral
Committee Member
Thatcher, Gregory R. Bruzik, Karol S. van Breemen, Richard B. Garcia-Martinez, JesusSubmitted date
2013-12Language
- en
Issue date
2014-02-24Usage metrics
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