Synthesis, Photoaffinity Labeling Studies, Biological Evaluation of Photoreactive Probes for HDAC2 and 8
thesisposted on 25.02.2016 by Aditya S. Vaidya
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
Histone deacetylases are validated targets for multiple therapeutic applications. Existing histone deacetylase inhibitors have a zinc chelating group, which limits their use due to metabolic instability.The presented work deals with exploration of novel binding sites in histone deacetylase 2 and 8 with photoreactive ligands for the design of histone deacetylase inhibitors without a zinc chelating group.