File(s) under embargo

430

days

15

hours

until file(s) become available

The Separate and Interactive Effects of HIV and APOE Genotype on Cognition among Women

thesis
posted on 01.12.2019 by John S Bark
Women with HIV are vulnerable to cognitive dysfunction compared to male counterparts. Genetic factors have not been widely examined as a contributor to cognitive dysfunction in HIV+ women. The goal of this study was to examine cognitive function in relation to Apolipoprotein E (APOE) genotype in HIV+ and HIV- women. A total of 714 women from the Women’s Interagency HIV Study (WIHS) (68.9% HIV+, 32.9% ε4+) had both longitudinal cognitive data over three visits and APOE genotyping available for analysis. We found there was no main effect of APOE genotype on any cognitive domain. We found a significant interactive effect of HIV, APOE and time on global cognition, driven by small negative effects of the APOE ε4 allele in the HIV- control group. Finally, we found that in HIV+ women, there was a significant interactive effect between APOE and age on executive functioning, global cognition, motor skills, and processing speed, such that older HIV+ ε4+ women performed worse than older HIV+ ε4- women. In contrast, there was no main effect of APOE ε4 carrier status on any cognitive domain in younger HIV+ women or either age group of HIV- controls. Overall, the current findings suggest that APOE genotype may be an age-related risk factor for cognitive dysfunction in HIV+ women.

History

Advisor

Maki, Pauline

Chair

Maki, Pauline

Department

Psychology

Degree Grantor

University of Illinois at Chicago

Degree Level

Masters

Degree name

MA, Master of Arts

Committee Member

Leshikar, Eric Ragozzino, Michael

Submitted date

December 2019

Thesis type

application/pdf

Language

en

Issue date

05/12/2019

Exports

Categories

Exports