Transition Metal-Catalyzed Intramolecular C-H Amination Reactions and Applications in Drug Discovery

2016-10-29T00:00:00Z (GMT) by Ashley L. Pumphrey
This thesis describes the development of methodology towards the formation of complex N-heterocycles via transition metal-mediated C-H amination of aryl azides. These novel reactions lead to the formation of α-, β-, γ-, and δ-carbolinium ions and the corresponding carbolines. These complex heterocylces are then used in the synthesis of new antischistosomal and pulmonary arterial hypertension therapeutic targets. Assay development is also carried out to test the potency of these novel inhibitors.