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Transition Metal-Catalyzed Intramolecular C-H Amination Reactions and Applications in Drug Discovery

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thesis
posted on 29.10.2016 by Ashley L. Pumphrey
This thesis describes the development of methodology towards the formation of complex N-heterocycles via transition metal-mediated C-H amination of aryl azides. These novel reactions lead to the formation of α-, β-, γ-, and δ-carbolinium ions and the corresponding carbolines. These complex heterocylces are then used in the synthesis of new antischistosomal and pulmonary arterial hypertension therapeutic targets. Assay development is also carried out to test the potency of these novel inhibitors.

History

Advisor

Driver, Tom G.

Department

Chemistry

Degree Grantor

University of Illinois at Chicago

Degree Level

Doctoral

Committee Member

Anderson, Laura L. Wardrop, Duncan Williams, David Wink, Donald

Submitted date

2014-08

Language

en

Issue date

28/10/2014

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