Transition Metal-Catalyzed Intramolecular C-H Amination Reactions and Applications in Drug Discovery
thesisposted on 29.10.2016 by Ashley L. Pumphrey
In order to distinguish essays and pre-prints from academic theses, we have a separate category. These are often much longer text based documents than a paper.
This thesis describes the development of methodology towards the formation of complex N-heterocycles via transition metal-mediated C-H amination of aryl azides. These novel reactions lead to the formation of α-, β-, γ-, and δ-carbolinium ions and the corresponding carbolines. These complex heterocylces are then used in the synthesis of new antischistosomal and pulmonary arterial hypertension therapeutic targets. Assay development is also carried out to test the potency of these novel inhibitors.