Now showing items 1-2 of 2

    • Decreased Warfarin Clearance with the CYP2C9 R150H (*8) Polymorphism 

      Liu, Yong; Jeong, Hyun-Young; Takahashi, Harumi; Drozda, Katarzyna; Patel, Shitalben R.; Shapiro, Nancy L.; Nutescu, Edith A.; Cavallari, Larisa H. (Nature Publishing Group, 2012-04)
      The cytochrome P450 (CYP) 2C9 R150H (*8) allele occurs commonly in African Americans and is associated with lower warfarin dose requirements. We examined whether the CYP2C9*8 allele impacts warfarin clearance through a ...
    • The Role of Pharmacogenomics in the Management of Traditional and Novel Oral Anticoagulants 

      Cavallari, Larisa H.; Shin, Jaekyu; Perera, Minoli A. (IOS Press, 2011-12)
      Warfarin is the most commonly prescribed oral anticoagulant. However, it remains a difficult drug to manage mostly because of its narrow therapeutic index and wide inter-patient variability in anticoagulant effects. Over ...