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    IgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis

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    Date
    2013-03
    Author
    Hvaring, Charlotte
    Vujicic, Snezana
    Aasly, Jan O.
    Feinstein, Douglas L.
    White, Linda R.
    Boullerne, Anne I.
    Publisher
    Elsevier
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    Abstract
    This study has established the presence of IgM against S-nitrosylated proteins in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope (anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal rather than the result of ingress from serum. Two correlations during relapse: between CSF level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker.
    Subject
    Multiple sclerosis
    Intrathecal synthesis
    IgM
    S-nitrosocysteine
    S-nitrosylation
    Biomarker
    Type
    Article
    Date available in INDIGO
    2013-10-22T21:41:21Z
    URI
    http://hdl.handle.net/10027/10108
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    • Publications - Anesthesiology

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