IgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis
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Date
2013-03Author
Hvaring, Charlotte
Vujicic, Snezana
Aasly, Jan O.
Feinstein, Douglas L.
White, Linda R.
Boullerne, Anne I.
Publisher
ElsevierMetadata
Show full item recordAbstract
This study has established the presence of IgM against S-nitrosylated proteins in
cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope
(anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in
CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence
from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal
rather than the result of ingress from serum. Two correlations during relapse: between CSF
level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum
anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker.
Subject
Multiple sclerosisIntrathecal synthesis
IgM
S-nitrosocysteine
S-nitrosylation
Biomarker