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dc.contributor.authorHvaring, Charlotte
dc.contributor.authorVujicic, Snezana
dc.contributor.authorAasly, Jan O.
dc.contributor.authorFeinstein, Douglas L.
dc.contributor.authorWhite, Linda R.
dc.contributor.authorBoullerne, Anne I.
dc.date.accessioned2013-10-22T21:41:21Z
dc.date.available2013-10-22T21:41:21Z
dc.date.issued2013-03
dc.identifier.bibliographicCitationHvaring C, Vujicic S, Aasly JO, Feinstein DL, White LR, Boullerne AI. IgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosis. Journal of Neuroimmunology. 2013 Mar 15;256(1-2):77-83. doi: 10.1016/j.jneuroim.2012.12.011.en_US
dc.identifier.issn1872-8421
dc.identifier.urihttp://hdl.handle.net/10027/10108
dc.descriptionNOTICE: This is the author’s version of a work that was accepted for publication in Journal of Neuroimmunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Neuroimmunology, Issue 1-2, 2013 DOI: 10.1016/j.jneuroim.2012.12.011en_US
dc.description.abstractThis study has established the presence of IgM against S-nitrosylated proteins in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients using S-nitrosocysteine epitope (anti-SNOcys) as previously shown in serum. Anti-SNOcys IgM increased significantly in CSF during relapsing-remitting MS compared to milder neurological conditions. Evidence from albumin, IgG and IgM suggest that the production of anti-SNOcys IgM is intrathecal rather than the result of ingress from serum. Two correlations during relapse: between CSF level of anti-SNOcys IgM and time elapsed since relapse onset; and between CSF and serum anti-SNOcys IgM levels, suggest that this antibody may have potential as a biomarker.en_US
dc.description.sponsorshipThis work was supported by the National Multiple Sclerosis Society, USA (PP1366 to A.I.B.), and a scholarship from the Norwegian University of Science and Technology (C.H.).en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectMultiple sclerosisen_US
dc.subjectIntrathecal synthesisen_US
dc.subjectIgMen_US
dc.subjectS-nitrosocysteineen_US
dc.subjectS-nitrosylationen_US
dc.subjectBiomarkeren_US
dc.titleIgM to S-nitrosylated protein is found intrathecally in relapsing-remitting multiple sclerosisen_US
dc.typeArticleen_US


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