Show simple item record

dc.contributor.advisorVarady, Krista A.en_US
dc.contributor.authorBhutani, Surabhien_US
dc.date.accessioned2013-10-31T19:57:52Z
dc.date.available2015-11-01T10:30:11Z
dc.date.created2013-08en_US
dc.date.issued2013-10-31
dc.date.submitted2013-08en_US
dc.identifier.urihttp://hdl.handle.net/10027/10358
dc.description.abstractObjective: The effect of alternate day fasting (ADF) combined with endurance exercise (Ex) on body weight, body composition, coronary heart disease risks and behavioral factors has never been tested. Method: Obese subjects (n = 64) were randomized to 1 of 4 groups: 1) combination (ADF + endurance exercise), 2) ADF, 3) exercise, or 4) control, for 12 weeks. Results: Body weight was reduced (P < 0.05) by 6 ± 4 kg, 3 ± 1 kg, and 1 ± 0 kg in the combination, ADF, and exercise group, respectively. Fat mass decreased (P < 0.001) while lean mass was retained in the combination group. LDL cholesterol decreased (12 ± 5%, P < 0.05) and HDL cholesterol increased (18 ± 9%, P < 0.05) in the combination group only. LDL particle size increased (P < 0.001) in both the combination and ADF group, while small HDL particles decreased (P < 0.01) in the combination group only. FMD increased by 5% only in the ADF group. Leptin decreased in the combination (34 ± 9 ng/ml, P < 0.001), ADF (10 ± 4 ng/ml, P < 0.05) and exercise group (11 ± 4 ng/ml, P < 0.05). Changes in FMD in the ADF group were not related to changes in leptin. With behavioral factors, subjects chose to exercise the same amount (P = 0.790) on the fast days (48 ± 2%) as feed days (52 ± 2%). Likelihood to cheat on the fast day was not higher if the subject exercised in the afternoon (17 ± 7%) versus the morning (10 ± 5%). Hunger decreased (P < 0.05) while satisfaction and fullness increased (P < 0.05) post-treatment in the ADF group only. Restrained eating increased (P < 0.05) and uncontrolled eating decreased (P < 0.05) in the combination and ADF groups. Conclusions: These findings suggest that the combination produces superior changes in body weight, body composition, and plasma lipids, when compared to individual treatments. ADF alone is an effective intervention to improve endothelial function. This combination therapy also leads to positive behavioral changes that may contribute to long-term steady weight loss.en_US
dc.language.isoenen_US
dc.subjectFastingen_US
dc.subjectcalorie restrictionen_US
dc.subjectendurance exerciseen_US
dc.subjectobesityen_US
dc.subjectcoronary heart diseaseen_US
dc.subjectweight lossen_US
dc.subjectbody compositionen_US
dc.subjectplasma lipidsen_US
dc.subjectadipokinesen_US
dc.subjectendothelial functionen_US
dc.subjectTFEQen_US
dc.subjecthungeren_US
dc.subjecteating behavioren_US
dc.titleAlternate Day Fasting Combined with Exercise for Weight Loss and Cardio-Protection in Obese Adultsen_US
thesis.degree.departmentKinesiology and Nutritionen_US
thesis.degree.disciplineKinesiology, Nutrition and Rehabilitation Sciencesen_US
thesis.degree.grantorUniversity of Illinois at Chicagoen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePhD, Doctor of Philosophyen_US
dc.type.genrethesisen_US
dc.contributor.committeeMemberBowen, Phyllis E.en_US
dc.contributor.committeeMemberPhillips, Shane A.en_US
dc.contributor.committeeMemberFantuzzi, Giamilaen_US
dc.contributor.committeeMemberMarquez, David X.en_US
dc.type.materialtexten_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record