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dc.contributor.authorKlempel, Monica C
dc.contributor.authorKroeger, Cynthia M
dc.contributor.authorBhutani, Surabhi
dc.contributor.authorTrepanowski, John F
dc.contributor.authorVarady, Krista A
dc.date.accessioned2013-12-06T23:30:55Z
dc.date.available2013-12-06T23:30:55Z
dc.date.issued2012-11
dc.identifier.bibliographicCitationKlempel MC, Kroeger CM, Bhutani S, Trepanowski JF, Varady KA. Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutrition Journal. Nov 2012;11. DOI: 10.1186/1475-2891-11-98en_US
dc.identifier.issn1475-2891
dc.identifier.urihttp://hdl.handle.net/10027/10866
dc.description© 2012 Klempel et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The original version is available through BioMed Central at DOI: 10.1186/1475-2891-11-98.en_US
dc.description.abstractBackground: Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown. Objective: This study examined the effects of IF plus CR (with or without a liquid diet) on body weight, body composition, and CHD risk. Methods: Obese women (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet. The trial had two phases: 1) 2-week weight maintenance period, and 2) 8-week weight loss period. Results: Body weight decreased more (P = 0.04) in the IFCR-L group (3.9 +/- 1.4 kg) versus the IFCR-F group (2.5 +/- 0.6 kg). Fat mass decreased similarly (P < 0.0001) in the IFCR-L and IFCR-F groups (2.8 +/- 1.2 kg and 1.9 +/- 0.7 kg, respectively). Visceral fat was reduced (P < 0.001) by IFCR-L (0.7 +/- 0.5 kg) and IFCR-F (0.3 +/- 0.5 kg) diets. Reductions in total and LDL cholesterol levels were greater (P = 0.04) in the IFCR-L (19 +/- 10%; 20 +/- 9%, respectively) versus the IFCR-F group (8 +/- 3%; 7 +/- 4%, respectively). LDL peak particle size increased (P < 0.01), while heart rate, glucose, insulin, and homocysteine decreased (P < 0.05), in the IFCR-L group only. Conclusion: These findings suggest that IF combined with CR and liquid meals is an effective strategy to help obese women lose weight and lower CHD risk.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.subjectIntermittent fastingen_US
dc.subjectCalorie restrictionen_US
dc.subjectLiquid dieten_US
dc.subjectBody Weighten_US
dc.subjectVisceral faten_US
dc.titleIntermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese womenen_US
dc.typeArticleen_US


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